Fcγ Receptor-induced Soluble Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) Production Inhibits Angiogenesis and Enhances Efficacy of Anti-tumor Antibodies

Monocytes/macrophages are potent mediators of antitumor antibody therapy, where they engage target cells via Fcγ receptors (FcγR). Binding of these cells to opsonized tumor targets elicits cytokine production, phagocytosis, and antibody-mediated cellular cytotoxicity. Here we show for the first time...

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Bibliografske podrobnosti
Main Authors: Justiniano, Steven E., Elavazhagan, Saranya, Fatehchand, Kavin, Shah, Prexy, Mehta, Payal, Roda, Julie M., Mo, Xiaokui, Cheney, Carolyn, Hertlein, Erin, Eubank, Timothy D., Marsh, Clay, Muthusamy, Natarajan, Butchar, Jonathan P., Byrd, John C., Tridandapani, Susheela
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772225/
https://ncbi.nlm.nih.gov/pubmed/23902770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.485185
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