Fcγ Receptor-induced Soluble Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) Production Inhibits Angiogenesis and Enhances Efficacy of Anti-tumor Antibodies

Monocytes/macrophages are potent mediators of antitumor antibody therapy, where they engage target cells via Fcγ receptors (FcγR). Binding of these cells to opsonized tumor targets elicits cytokine production, phagocytosis, and antibody-mediated cellular cytotoxicity. Here we show for the first time...

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Détails bibliographiques
Auteurs principaux: Justiniano, Steven E., Elavazhagan, Saranya, Fatehchand, Kavin, Shah, Prexy, Mehta, Payal, Roda, Julie M., Mo, Xiaokui, Cheney, Carolyn, Hertlein, Erin, Eubank, Timothy D., Marsh, Clay, Muthusamy, Natarajan, Butchar, Jonathan P., Byrd, John C., Tridandapani, Susheela
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2013
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772225/
https://ncbi.nlm.nih.gov/pubmed/23902770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.485185
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