Fcγ Receptor-induced Soluble Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) Production Inhibits Angiogenesis and Enhances Efficacy of Anti-tumor Antibodies

Monocytes/macrophages are potent mediators of antitumor antibody therapy, where they engage target cells via Fcγ receptors (FcγR). Binding of these cells to opsonized tumor targets elicits cytokine production, phagocytosis, and antibody-mediated cellular cytotoxicity. Here we show for the first time...

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Hlavní autoři: Justiniano, Steven E., Elavazhagan, Saranya, Fatehchand, Kavin, Shah, Prexy, Mehta, Payal, Roda, Julie M., Mo, Xiaokui, Cheney, Carolyn, Hertlein, Erin, Eubank, Timothy D., Marsh, Clay, Muthusamy, Natarajan, Butchar, Jonathan P., Byrd, John C., Tridandapani, Susheela
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772225/
https://ncbi.nlm.nih.gov/pubmed/23902770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.485185
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