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Mutational Constraints on Local Unfolding Inhibit the Rheological Adaptation of von Willebrand Factor
Unusually large von Willebrand factor (VWF), the first responder to vascular injury in primary hemostasis, is designed to capture platelets under the high shear stress of rheological blood flow. In type 2M von Willebrand disease, two rare mutations (G1324A and G1324S) within the platelet GPIbα bindi...
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| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4759165/ https://ncbi.nlm.nih.gov/pubmed/26677223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.703850 |
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