Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment

In a positron-emission tomography (PET) study with the β-amyloid (Aβ) tracer [(18)F]-florbetaben, we previously showed that Aβ deposition in transgenic mice expressing Swedish mutant APP (APP-Swe) mice can be tracked in vivo. γ-Secretase modulators (GSMs) are promising therapeutic agents by reducing...

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Publicat a:Mol Psychiatry
Autors principals: Brendel, M, Jaworska, A, Herms, J, Trambauer, J, Rötzer, C, Gildehaus, F-J, Carlsen, J, Cumming, P, Bylund, J, Luebbers, T, Bartenstein, P, Steiner, H, Haass, C, Baumann, K, Rominger, A
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759098/
https://ncbi.nlm.nih.gov/pubmed/26055427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.74
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