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APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication

APOBEC family cytidine deaminases have been recently implicated as powerful mutators of cancer genomes. How APOBECs, which are ssDNA specific enzymes, gain access to chromosomal DNA is unclear. To ascertain the chromosomal ssDNA substrates of the APOBECs, we expressed APOBEC3A and APOBEC3B, the two...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Hoopes, James, Cortez, Luis, Mertz, Tony, Malc, Ewa P., Mieczkowski, Piotr A., Roberts, Steven A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758883/
https://ncbi.nlm.nih.gov/pubmed/26832400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.01.021
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