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APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication
APOBEC family cytidine deaminases have been recently implicated as powerful mutators of cancer genomes. How APOBECs, which are ssDNA specific enzymes, gain access to chromosomal DNA is unclear. To ascertain the chromosomal ssDNA substrates of the APOBECs, we expressed APOBEC3A and APOBEC3B, the two...
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| Publicado en: | Cell Rep |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4758883/ https://ncbi.nlm.nih.gov/pubmed/26832400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.01.021 |
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