(+)-Pentazocine Reduces NMDA-Induced Murine Retinal Ganglion Cell Death Through a σR1-Dependent Mechanism

PURPOSE: To evaluate, in vivo, the effects of the sigma-1 receptor (σR1) agonist, (+)-pentazocine, on N-methyl-D-aspartate (NMDA)-mediated retinal excitotoxicity. METHODS: Intravitreal NMDA injections were performed in C57BL/6J mice (wild type [WT]) and σR1(−/−) (σR1 knockout [KO]) mice. Fellow eyes...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Zhao, Jing, Mysona, Barbara A., Qureshi, Azam, Kim, Lily, Fields, Taylor, Gonsalvez, Graydon B., Smith, Sylvia B., Bollinger, Kathryn E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2016
Témata:
Retina
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758298/
https://ncbi.nlm.nih.gov/pubmed/26868747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-18565
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