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Prevention of Excitotoxicity in Primary Retinal Ganglion Cells by (+)-Pentazocine, a Sigma Receptor-1-Specific Ligand

PURPOSE: σRs are non-opioid, non-phencyclidine binding sites with robust neuroprotective properties. Previously, we induced death in the RGC-5 cell line using very high concentrations (1 mM) of the excitatory amino acids glutamate (Glu) and homocysteine (Hcy) and demonstrated that the σR1 ligand (+)...

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Main Authors: Dun, Ying, Thangaraju, Muthusamy, Prasad, Puttur, Ganapathy, Vadivel, Smith, Sylvia B.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742388/
https://ncbi.nlm.nih.gov/pubmed/17898305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.07-0343
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