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Early phase clinical trials—are dose expansion cohorts needed?

Dose-expansion cohorts (DECs) enable investigators to identify potentially effective drugs, for specific patient populations, in a single trial by assessing antitumour activity as early as possible. We discuss how the objectives, design and interpretation of DEC have evolved, and how DECs are changi...

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Bibliografiska uppgifter
I publikationen:Nat Rev Clin Oncol
Huvudupphovsmän: Iasonos, Alexia, O’Quigley, John
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758199/
https://ncbi.nlm.nih.gov/pubmed/26441082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrclinonc.2015.174
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