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SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons
Defects in DNA repair have been linked to cognitive decline with age and neurodegenerative disease. Yet the mechanisms that protect neurons from genotoxic stress remain largely obscure. In this report, we characterize the roles of the NAD(+)-dependent deacetylase, SIRT1, in the neuronal response to...
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| Izdano u: | Nat Neurosci |
|---|---|
| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4758134/ https://ncbi.nlm.nih.gov/pubmed/23852118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3460 |
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