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A novel pathway regulates memory and plasticity via SIRT1 and miR-134
The NAD-dependent deacetylase Sir2 was initially identified as a mediator of replicative lifespan in budding yeast and was subsequently shown to modulate longevity in worms and flies1,2. Its mammalian homologue, SIRT1, appears to have evolved complex systemic roles in cardiac function, DNA repair, a...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928875/ https://ncbi.nlm.nih.gov/pubmed/20622856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09271 |
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