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Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1
SIRT1, a NAD+-dependent deacetylase, protects neurons in a variety of in vitro and in vivo models of neurodegenerative disease. We have previously described a neuroprotective effect by SIRT1 independent of its catalytic activity. To confirm this conclusion we tested a panel of SIRT1 deletion mutant...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6459503/ https://ncbi.nlm.nih.gov/pubmed/30973934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0215208 |
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