Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1

SIRT1, a NAD+-dependent deacetylase, protects neurons in a variety of in vitro and in vivo models of neurodegenerative disease. We have previously described a neuroprotective effect by SIRT1 independent of its catalytic activity. To confirm this conclusion we tested a panel of SIRT1 deletion mutant...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Pfister, Jason A., Ma, Chi, D’Mello, Santosh R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459503/
https://ncbi.nlm.nih.gov/pubmed/30973934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0215208
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