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A generic selection system for improved expression and thermostability of G protein-coupled receptors by directed evolution
Structural and biophysical studies as well as drug screening approaches on G protein-coupled receptors (GPCRs) have been largely hampered by the poor biophysical properties and low expression yields of this largest class of integral membrane proteins. Thermostabilisation of GPCRs by introduction of...
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| Yayımlandı: | Sci Rep |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4758055/ https://ncbi.nlm.nih.gov/pubmed/26887595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21294 |
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