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Directed evolution for high functional production and stability of a challenging G protein-coupled receptor

Membrane proteins such as G protein-coupled receptors (GPCRs) carry out many fundamental biological functions, are involved in a large number of physiological responses, and are thus important drug targets. To allow detailed biophysical and structural studies, most of these important receptors have...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Waltenspühl, Yann, Jeliazkov, Jeliazko R., Kummer, Lutz, Plückthun, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8060309/
https://ncbi.nlm.nih.gov/pubmed/33883583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87793-9
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