Blimp-1 controls plasma cell function through regulation of immunoglobulin secretion and the unfolded protein response

Plasma cell differentiation requires silencing of B cell transcription, while establishing antibody-secretory function and long-term survival. The transcription factors Blimp-1 and IRF4 are essential for plasma cell generation, however their function in mature plasma cells has remained elusive. We h...

Full description

Saved in:
Bibliographic Details
Published in:Nat Immunol
Main Authors: Tellier, Julie, Shi, Wei, Minnich, Martina, Liao, Yang, Crawford, Simon, Smyth, Gordon K, Kallies, Axel, Busslinger, Meinrad, Nutt, Stephen L
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757736/
https://ncbi.nlm.nih.gov/pubmed/26779600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3348
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items