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Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self‐reactive plasma cells
The transcription factor Blimp1 is not only an essential regulator of plasma cells, but also a risk factor for the development of autoimmune disease in humans. Here, we demonstrate in the mouse that the Prdm1 (Blimp1) gene was partially activated at the chromatin and transcription level in early B c...
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| Publié dans: | EMBO J |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6331720/ https://ncbi.nlm.nih.gov/pubmed/30498131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100010 |
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