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Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells
The establishment of a diverse B cell antigen receptor (BCR) repertoire by V(D)J recombination also generates autoreactive B cells. Anergy is one tolerance mechanism, which renders autoreactive B cells insensitive to stimulation by self-antigen, whereas Toll-like receptor (TLR) signaling can reactiv...
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| Publicado no: | Nat Immunol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7115902/ https://ncbi.nlm.nih.gov/pubmed/31591571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0490-2 |
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