Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN downregulation

The transcription factor Pax5 controls B cell development, but its role in mature B cells is largely enigmatic. Here, we demonstrated loss of Pax5 by conditional mutagenesis in peripheral B lymphocytes led to the significant reduction of B-1a, marginal zone (MZ) and germinal center (GC) B cells as w...

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Détails bibliographiques
Publié dans:Sci Immunol
Auteurs principaux: Calderón, Lesly, Schindler, Karina, Malin, Stephen G., Schebesta, Alexandra, Sun, Qiong, Schwickert, Tanja, Alberti, Chiara, Fischer, Maria, Jaritz, Markus, Tagoh, Hiromi, Ebert, Anja, Minnich, Martina, Liston, Adrian, Cochella, Luisa, Busslinger, Meinrad
Format: Artigo
Langue:Inglês
Publié: 2021
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611449/
https://ncbi.nlm.nih.gov/pubmed/34301800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abg5003
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