The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis

Pax5 controls the identity and development of B cells by repressing lineage-inappropriate genes and activating B-cell-specific genes. Here, we used genome-wide approaches to identify Pax5 target genes in pro-B and mature B cells. In these cell types, Pax5 bound to 40% of the cis-regulatory elements...

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Detaylı Bibliyografya
Asıl Yazarlar: Revilla-i-Domingo, Roger, Bilic, Ivan, Vilagos, Bojan, Tagoh, Hiromi, Ebert, Anja, Tamir, Ido M, Smeenk, Leonie, Trupke, Johanna, Sommer, Andreas, Jaritz, Markus, Busslinger, Meinrad
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400013/
https://ncbi.nlm.nih.gov/pubmed/22669466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.155
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