Stage-specific control of early B cell development by the transcription factor Ikaros

Ikaros is an essential regulator of lymphopoiesis. Here, we studied the B-cell-specific function of Ikaros by conditional Ikzf1 inactivation in pro-B cells. B-cell development was arrested at an aberrant ‘pro-B’ cell stage characterized by increased cell adhesion and loss of pre-B cell receptor sign...

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Publicado no:Nat Immunol
Main Authors: Schwickert, Tanja A., Tagoh, Hiromi, Gültekin, Sinan, Dakic, Aleksandar, Axelsson, Elin, Minnich, Martina, Ebert, Anja, Werner, Barbara, Roth, Mareike, Cimmino, Luisa, Dickins, Ross A., Zuber, Johannes, Jaritz, Markus, Busslinger, Meinrad
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790181/
https://ncbi.nlm.nih.gov/pubmed/24509509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2828
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