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Structural requirements for protein-catalyzed annealing of U4 and U6 RNAs during di-snRNP assembly

Base-pairing of U4 and U6 snRNAs during di-snRNP assembly requires large-scale remodeling of RNA structure that is chaperoned by the U6 snRNP protein Prp24. We investigated the mechanism of U4/U6 annealing in vitro using an assay that enables visualization of ribonucleoprotein complexes and faithful...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Didychuk, Allison L., Montemayor, Eric J., Brow, David A., Butcher, Samuel E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2016
Ämnen:
RNA
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756825/
https://ncbi.nlm.nih.gov/pubmed/26673715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1374
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