Impact of clinically tested NEP/ACE inhibitors on tumor uptake of [(111)In-DOTA]MG11—first estimates for clinical translation

BACKGROUND: We have recently shown that treatment of mice with the neutral endopeptidase (NEP) inhibitor phosphoramidon (PA) improves the bioavailability and tumor uptake of biodegradable radiopeptides. For the truncated gastrin radiotracer [(111)In-DOTA]MG11 ([(DOTA)DGlu(10)]gastrin(10–17)), this m...

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Bibliographic Details
Published in:EJNMMI Res
Main Authors: Kaloudi, Aikaterini, Nock, Berthold A., Lymperis, Emmanouil, Valkema, Roelf, Krenning, Eric P., de Jong, Marion, Maina, Theodosia
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2016
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755954/
https://ncbi.nlm.nih.gov/pubmed/26882895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-015-0158-3
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