Differential Regulation of ZEB1 and EMT by MAPK-interacting protein kinases (MNKs) and eIF4E in Pancreatic Cancer

Human pancreatic ductal adenocarcinoma (PDAC) tumors are associated with dysregulation of mRNA translation. In this report, it is demonstrated that PDAC cells grown in collagen exhibit increased activation of the MAPK-interacting protein kinases (MNKs) that mediate eIF4E phosphorylation. Pharmacolog...

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Publicado no:Mol Cancer Res
Main Authors: Kumar, Krishan, Chow, Christina R., Ebine, Kazumi, Arslan, Ahmet D., Kwok, Benjamin, Bentrem, David J., Eckerdt, Frank D., Platanias, Leonidas C., Munshi, Hidayatullah G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755915/
https://ncbi.nlm.nih.gov/pubmed/26609108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0285
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