MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL

The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development and maintenance. Here, we interrogate the MNK-eIF4E axis in diffuse large B-cell lymphoma (DLBCL) and show a distinct distribution of MNK1 and...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Landon, Ari L., Muniandy, Parameswary A., Shetty, Amol C., Lehrmann, Elin, Volpon, Laurent, Houng, Simone, Zhang, Yongqing, Dai, Bojie, Peroutka, Raymond, Mazan-Mamczarz, Krystyna, Steinhardt, James, Mahurkar, Anup, Becker, Kevin G., Borden, Katherine L., Gartenhaus, Ronald B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4238046/
https://ncbi.nlm.nih.gov/pubmed/25403230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6413
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados