CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors

The role that anergy, an acquired state of T cell functional unresponsiveness, plays in natural peripheral tolerance remains unclear. In this study, we demonstrate that anergy is selectively induced in fetal antigen-specific maternal CD4(+) T cells during pregnancy. A naturally occurring subpopulati...

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Pubblicato in:Nat Immunol
Autori principali: Kalekar, Lokesh A., Schmiel, Shirdi E., Nandiwada, Sarada L., Lam, Wing Y., Barsness, Laura O., Zhang, Na, Stritesky, Gretta L., Malhotra, Deepali, Pauken, Kristen E., Linehan, Jonathan L., O’Sullivan, M. Gerard, Fife, Brian T., Hogquist, Kristin A., Jenkins, Marc K., Mueller, Daniel L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755884/
https://ncbi.nlm.nih.gov/pubmed/26829766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3331
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