CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors

The role that anergy, an acquired state of T cell functional unresponsiveness, plays in natural peripheral tolerance remains unclear. In this study, we demonstrate that anergy is selectively induced in fetal antigen-specific maternal CD4(+) T cells during pregnancy. A naturally occurring subpopulati...

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Bibliografski detalji
Izdano u:Nat Immunol
Glavni autori: Kalekar, Lokesh A., Schmiel, Shirdi E., Nandiwada, Sarada L., Lam, Wing Y., Barsness, Laura O., Zhang, Na, Stritesky, Gretta L., Malhotra, Deepali, Pauken, Kristen E., Linehan, Jonathan L., O’Sullivan, M. Gerard, Fife, Brian T., Hogquist, Kristin A., Jenkins, Marc K., Mueller, Daniel L.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755884/
https://ncbi.nlm.nih.gov/pubmed/26829766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3331
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