Cutting Edge: Type 1 Diabetes Occurs despite Robust Anergy among Endogenous Insulin-Specific CD4 T Cells in NOD Mice

Insulin-specific CD4(+) T cells are required for type 1 diabetes. How these cells are regulated and how tolerance breaks down are poorly understood because of a lack of reagents. Therefore, we used an enrichment method and tetramer reagents to track insulin-specific CD4(+) T cells in diabetes-suscep...

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Hlavní autoři: Pauken, Kristen E., Linehan, Jonathan L., Spanier, Justin A., Sahli, Nathanael L., Kalekar, Lokesh A., Binstadt, Bryce A., Moon, James J., Mueller, Daniel L., Jenkins, Marc K., Fife, Brian T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987747/
https://ncbi.nlm.nih.gov/pubmed/24123682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301927
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