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The serotonin aldehyde, 5-HIAL, oligomerizes alpha-synuclein
In Parkinson’s disease (PD) alpha-synuclein oligomers are thought to be pathogenic, and 3,4-dihydroxyphenylacetaldehyde (DOPAL), an obligate aldehyde intermediate in neuronal dopamine metabolism, potently oligomerizes alpha-synuclein. PD involves alpha-synuclein deposition in brainstem raphe nuclei;...
Gorde:
| Argitaratua izan da: | Neurosci Lett |
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| Egile Nagusiak: | , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2015
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4755587/ https://ncbi.nlm.nih.gov/pubmed/25637699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2015.01.064 |
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