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Rotenone Decreases Intracellular Aldehyde Dehydrogenase Activity: Implications for the Pathogenesis of Parkinson Disease

Repeated systemic administration of the mitochondrial complex I inhibitor rotenone produces a rodent model of Parkinson disease (PD). Mechanisms of relatively selective rotenone-induced damage to nigrostriatal dopaminergic neurons remain incompletely understood. According to the “catecholaldehyde hy...

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Detalhes bibliográficos
Publicado no:J Neurochem
Main Authors: Goldstein, David S., Sullivan, Patti, Cooney, Adele, Jinsmaa, Yunden, Kopin, Irwin J., Sharabi, Yehonatan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361358/
https://ncbi.nlm.nih.gov/pubmed/25645689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13042
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