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Benomyl, Aldehyde Dehydrogenase, DOPAL, and the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson’s Disease
[Image: see text] The dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) is detoxified mainly by aldehyde dehydrogenase (ALDH). We find that the fungicide benomyl potently and rapidly inhibits ALDH and builds up DOPAL in vivo in mouse striatum and in vitro in PC12 cells and human cultured f...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2014
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4137984/ https://ncbi.nlm.nih.gov/pubmed/25045800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx5002223 |
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