Benomyl, Aldehyde Dehydrogenase, DOPAL, and the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson’s Disease

[Image: see text] The dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) is detoxified mainly by aldehyde dehydrogenase (ALDH). We find that the fungicide benomyl potently and rapidly inhibits ALDH and builds up DOPAL in vivo in mouse striatum and in vitro in PC12 cells and human cultured f...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Casida, John E., Ford, Breanna, Jinsmaa, Yunden, Sullivan, Patti, Cooney, Adele, Goldstein, David S.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137984/
https://ncbi.nlm.nih.gov/pubmed/25045800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx5002223
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars