Benomyl, Aldehyde Dehydrogenase, DOPAL, and the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson’s Disease

[Image: see text] The dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) is detoxified mainly by aldehyde dehydrogenase (ALDH). We find that the fungicide benomyl potently and rapidly inhibits ALDH and builds up DOPAL in vivo in mouse striatum and in vitro in PC12 cells and human cultured f...

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Bibliografski detalji
Glavni autori: Casida, John E., Ford, Breanna, Jinsmaa, Yunden, Sullivan, Patti, Cooney, Adele, Goldstein, David S.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137984/
https://ncbi.nlm.nih.gov/pubmed/25045800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx5002223
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