Synthesis and Evaluation of 1,7-Diheteroarylhepta-1,4,6-trien-3-ones as Curcumin-Based Anticancer Agents

Thirty (1E,4E,6E)-1,7-diaryl-1,4,6-heptatrien-3-ones, featuring a central linear trienone linker and two identical nitrogen-containing heteroaromatic rings, were designed and synthesized as curcumin-based anticancer agents on the basis of their structural similarity to the enol-tautomer of curcumin,...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Wang, Rubing, Zhang, Xiaojie, Chen, Chengsheng, Chen, Guanglin, Zhong, Qiu, Zhang, Qiang, Zheng, Shilong, Wang, Guangdi, Chen, Qiao-Hong
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754155/
https://ncbi.nlm.nih.gov/pubmed/26827161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.01.017
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