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Design, Synthesis, and Biological Evaluation of 1,9-Diheteroarylnona-1,3,6,8-tetraen-5-ones as a New Class of Anti-Prostate Cancer Agents

In search of more effective chemotherapeutics for the treatment of castration-resistant prostate cancer and inspired by curcumin analogues, twenty five (1E,3E,6E,8E)-1,9-diarylnona-1,3,6,8-tetraen-5-ones bearing two identical terminal heteroaromatic rings have been successfully synthesized through W...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Zhang, Xiaojie, Wang, Rubing, Perez, German Ruiz, Chen, Guanglin, Zhang, Qiang, Zheng, Shilong, Wang, Guangdi, Chen, Qiao-Hong
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014612/
https://ncbi.nlm.nih.gov/pubmed/27543391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.08.006
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