Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects

Genetic studies have revealed significant overlaps of risk genes among psychiatric disorders. However, it is not clear how different mutations of the same gene contribute to different disorders. We characterized two lines of mutant mice with Shank3 mutations linked to ASD and schizophrenia. We found...

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Publicado no:Neuron
Main Authors: Zhou, Yang, Kaiser, Tobias, Monteiro, Patrícia, Zhang, Xiangyu, Van der Goes, Marie. S., Wang, Dongqing, Barak, Boaz, Zeng, Menglong, Li, Chenchen, Lu, Congyi, Wells, Michael, Amaya, Aldo, Nguyen, Shannon, Lewis, Michael, Sanjana, Neville, Zhou, Yongdi, Zhang, Mingjie, Zhang, Feng, Fu, Zhanyan, Feng, Guoping
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754122/
https://ncbi.nlm.nih.gov/pubmed/26687841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.11.023
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