Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects

Genetic studies have revealed significant overlaps of risk genes among psychiatric disorders. However, it is not clear how different mutations of the same gene contribute to different disorders. We characterized two lines of mutant mice with Shank3 mutations linked to ASD and schizophrenia. We found...

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Détails bibliographiques
Publié dans:Neuron
Auteurs principaux: Zhou, Yang, Kaiser, Tobias, Monteiro, Patrícia, Zhang, Xiangyu, Van der Goes, Marie. S., Wang, Dongqing, Barak, Boaz, Zeng, Menglong, Li, Chenchen, Lu, Congyi, Wells, Michael, Amaya, Aldo, Nguyen, Shannon, Lewis, Michael, Sanjana, Neville, Zhou, Yongdi, Zhang, Mingjie, Zhang, Feng, Fu, Zhanyan, Feng, Guoping
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754122/
https://ncbi.nlm.nih.gov/pubmed/26687841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.11.023
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