Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism

The postsynaptic scaffolding protein SH3 and multiple ankyrin repeat domains 3 (SHANK3) is critical for the development and function of glutamatergic synapses. Disruption of the SHANK3-encoding gene has been strongly implicated as a monogenic cause of autism, and Shank3 mutant mice show repetitive g...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wang, Wenting, Li, Chenchen, Chen, Qian, van der Goes, Marie-Sophie, Hawrot, James, Yao, Annie Y., Gao, Xian, Lu, Congyi, Zang, Ying, Zhang, Qiangge, Lyman, Katherine, Wang, Dongqing, Guo, Baolin, Wu, Shengxi, Gerfen, Charles R., Fu, Zhanyan, Feng, Guoping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409790/
https://ncbi.nlm.nih.gov/pubmed/28414301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87997
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