A Paclitaxel-Loaded Recombinant Polypeptide Nanoparticle Outperforms Abraxane in Multiple Murine Cancer Models

Packaging clinically relevant hydrophobic drugs into a self-assembled nanoparticle can improve their aqueous solubility, plasma half-life, tumor specific uptake and therapeutic potential. To this end, here we conjugated paclitaxel (PTX) to recombinant chimeric polypeptides (CPs) that spontaneously s...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Bhattacharyya, Jayanta, Bellucci, Joseph J., Weitzhandler, Isaac, McDaniel, Jonathan R., Spasojevic, Ivan, Li, Xinghai, Lin, Chao-Chieh, Chi, Jen-Tsan Ashley, Chilkoti, Ashutosh
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753781/
https://ncbi.nlm.nih.gov/pubmed/26239362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8939
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