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Encapsulating a Hydrophilic Chemotherapeutic into Rod-like Nanoparticles of a Genetically Encoded Asymmetric Triblock Polypeptide Improves its Efficacy

Encapsulating hydrophilic chemotherapeutics into the core of polymeric nanoparticles can improve their therapeutic efficacy by increasing their plasma half-life, tumor accumulation and intracellular uptake, and by protecting them from premature degradation. To achieve these goals, we designed a reco...

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Detalhes bibliográficos
Publicado no:Adv Funct Mater
Main Authors: Bhattacharyya, Jayanta, Weitzhandler, Isaac, Ho, Shihan Bryan, McDaniel, Jonathan R., Li, Xinghai, Tang, Lei, Liu, Jinyao, Dewhirst, Mark, Chilkoti, Ashutosh
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178977/
https://ncbi.nlm.nih.gov/pubmed/30319320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adfm.201605421
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