NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis

Cutaneous SCC (cSCC) is the most frequent skin cancer with metastatic potential and can manifest rapidly as a common side effect in patients receiving systemic kinase inhibitors. Here we use massively parallel exome and targeted level sequencing 132 sporadic cSCC, 39 squamoproliferative lesions and...

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Detalhes bibliográficos
Publicado no:J Invest Dermatol
Principais autores: South, Andrew P, Purdie, Karin J, Watt, Stephen A, Haldenby, Sam, den Breems, Nicoline, Dimon, Michelle, Arron, Sarah T, Kluk, Michael J, Aster, Jon C, McHugh, Angela, Xue, Dylan J, Dayal, Jasbani HS, Robinson, Kim S, Rizvi, SM Hasan, Proby, Charlotte M, Harwood, Catherine A, Leigh, Irene M
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753672/
https://ncbi.nlm.nih.gov/pubmed/24662767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2014.154
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