NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis

Cutaneous SCC (cSCC) is the most frequent skin cancer with metastatic potential and can manifest rapidly as a common side effect in patients receiving systemic kinase inhibitors. Here we use massively parallel exome and targeted level sequencing 132 sporadic cSCC, 39 squamoproliferative lesions and...

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Publicado en:J Invest Dermatol
Autores principales: South, Andrew P, Purdie, Karin J, Watt, Stephen A, Haldenby, Sam, den Breems, Nicoline, Dimon, Michelle, Arron, Sarah T, Kluk, Michael J, Aster, Jon C, McHugh, Angela, Xue, Dylan J, Dayal, Jasbani HS, Robinson, Kim S, Rizvi, SM Hasan, Proby, Charlotte M, Harwood, Catherine A, Leigh, Irene M
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753672/
https://ncbi.nlm.nih.gov/pubmed/24662767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2014.154
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