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Asymmetric Preorganization of Inverted Pair Residues in the Sodium-Calcium Exchanger
In analogy with many other proteins, Na(+)/Ca(2+) exchangers (NCX) adapt an inverted twofold symmetry of repeated structural elements, while exhibiting a functional asymmetry by stabilizing an outward-facing conformation. Here, structure-based mutant analyses of the Methanococcus jannaschii Na(+)/Ca...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4753433/ https://ncbi.nlm.nih.gov/pubmed/26876271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20753 |
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