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Population Shift Underlies Ca(2+)-induced Regulatory Transitions in the Sodium-Calcium Exchanger (NCX)
In eukaryotic Na(+)/Ca(2+) exchangers (NCX) the Ca(2+) binding CBD1 and CBD2 domains form a two-domain regulatory tandem (CBD12). An allosteric Ca(2+) sensor (Ca3–Ca4 sites) is located on CBD1, whereas CBD2 contains a splice-variant segment. Recently, a Ca(2+)-driven interdomain switch has been desc...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3743486/ https://ncbi.nlm.nih.gov/pubmed/23798674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.471698 |
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