Alternative Pathway Inhibition by Exogenous Factor H Fails to Attenuate Inflammation and Vascular Leakage in Experimental Pneumococcal Sepsis in Mice

Streptococcus pneumoniae is a common cause of sepsis. Effective complement activation is an important component of host defence against invading pathogens, whilst excessive complement activation has been associated with endothelial dysfunction and organ damage. The alternative pathway amplification...

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Publicado en:PLoS One
Autores principales: van der Maten, Erika, van Selm, Saskia, Langereis, Jeroen D., Bootsma, Hester J., van Opzeeland, Fred J. H., de Groot, Ronald, de Jonge, Marien I., van der Flier, Michiel
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752313/
https://ncbi.nlm.nih.gov/pubmed/26872035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149307
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