Alternative Pathway Inhibition by Exogenous Factor H Fails to Attenuate Inflammation and Vascular Leakage in Experimental Pneumococcal Sepsis in Mice

Streptococcus pneumoniae is a common cause of sepsis. Effective complement activation is an important component of host defence against invading pathogens, whilst excessive complement activation has been associated with endothelial dysfunction and organ damage. The alternative pathway amplification...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: van der Maten, Erika, van Selm, Saskia, Langereis, Jeroen D., Bootsma, Hester J., van Opzeeland, Fred J. H., de Groot, Ronald, de Jonge, Marien I., van der Flier, Michiel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752313/
https://ncbi.nlm.nih.gov/pubmed/26872035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149307
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