Polychlorinated Biphenyl-Xenobiotic Nuclear Receptor Interactions Regulate Energy Metabolism, Behavior, and Inflammation in Non-alcoholic-Steatohepatitis

Polychlorinated biphenyls (PCBs) are environmental pollutants associated with non-alcoholic-steatohepatitis (NASH), diabetes, and obesity. We previously demonstrated that the PCB mixture, Aroclor 1260, induced steatohepatitis and activated nuclear receptors in a diet-induced obesity mouse model. Thi...

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Опубликовано в: :Toxicol Sci
Главные авторы: Wahlang, Banrida, Prough, Russell A., Falkner, K. Cameron, Hardesty, Josiah E., Song, Ming, Clair, Heather B., Clark, Barbara J., States, J. Christopher, Arteel, Gavin E., Cave, Matthew C.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2016
Предметы:
Polychlorinated Biphenyls, PXR, CAR, and NASH
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751229/
https://ncbi.nlm.nih.gov/pubmed/26612838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv250
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