NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

NLRC5 is a transcriptional regulator of MHC class I (MHCI), which maintains high MHCI expression particularly in T cells. Recent evidence highlights an important NK–T-cell crosstalk, raising the question on whether NLRC5 specifically modulates this interaction. Here we show that NK cells from Nlrc5-...

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Pubblicato in:Nat Commun
Autori principali: Ludigs, Kristina, Jandus, Camilla, Utzschneider, Daniel T., Staehli, Francesco, Bessoles, Stéphanie, Dang, Anh Thu, Rota, Giorgia, Castro, Wilson, Zehn, Dietmar, Vivier, Eric, Held, Werner, Romero, Pedro, Guarda, Greta
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749981/
https://ncbi.nlm.nih.gov/pubmed/26861112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10554
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