NLRC5 Exclusively Transactivates MHC Class I and Related Genes through a Distinctive SXY Module

MHC class II (MHCII) genes are transactivated by the NOD-like receptor (NLR) family member CIITA, which is recruited to SXY enhancers of MHCII promoters via a DNA-binding “enhanceosome” complex. NLRC5, another NLR protein, was recently found to control transcription of MHC class I (MHCI) genes. Howe...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Ludigs, Kristina, Seguín-Estévez, Queralt, Lemeille, Sylvain, Ferrero, Isabel, Rota, Giorgia, Chelbi, Sonia, Mattmann, Chantal, MacDonald, H. Robson, Reith, Walter, Guarda, Greta
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374748/
https://ncbi.nlm.nih.gov/pubmed/25811463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005088
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