Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

The phosphatase Shp-2 was implicated in NK cell development and functions due to its interaction with NK inhibitory receptors, but its exact role in NK cells is still unclear. Here we show, using mice conditionally deficient for Shp-2 in the NK lineage, that NK cell development and responsiveness ar...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Niogret, Charlène, Miah, S. M. Shahjahan, Rota, Giorgia, Fonta, Nicolas P., Wang, Haiping, Held, Werner, Birchmeier, Walter, Sexl, Veronica, Yang, Wentian, Vivier, Eric, Ho, Ping-Chih, Brossay, Laurent, Guarda, Greta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441079/
https://ncbi.nlm.nih.gov/pubmed/30926899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09431-3
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