Unravelling druggable signalling networks that control F508del-CFTR proteostasis

Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator (CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is, in the misfolding and intracellular degradation of the protein. The F508del-CFTR proteostasis machinery and its homeostati...

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Publicat a:eLife
Autors principals: Hegde, Ramanath Narayana, Parashuraman, Seetharaman, Iorio, Francesco, Ciciriello, Fabiana, Capuani, Fabrizio, Carissimo, Annamaria, Carrella, Diego, Belcastro, Vincenzo, Subramanian, Advait, Bounti, Laura, Persico, Maria, Carlile, Graeme, Galietta, Luis, Thomas, David Y, Di Bernardo, Diego, Luini, Alberto
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2015
Matèries:
Computational and Systems Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749566/
https://ncbi.nlm.nih.gov/pubmed/26701908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10365
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