Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

BACKGROUND AND PURPOSE: The most common mutation in cystic fibrosis (CF), F508del, causes defects in trafficking, channel gating and endocytosis of the CF transmembrane conductance regulator (CFTR) protein. Because CF is an orphan disease, therapeutic strategies aimed at improving mutant CFTR functi...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Norez, C, Vandebrouck, C, Bertrand, J, Noel, S, Durieu, E, Oumata, N, Galons, H, Antigny, F, Chatelier, A, Bois, P, Meijer, L, Becq, F
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294108/
https://ncbi.nlm.nih.gov/pubmed/25065395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12859
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