Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

BACKGROUND AND PURPOSE: The most common mutation in cystic fibrosis (CF), F508del, causes defects in trafficking, channel gating and endocytosis of the CF transmembrane conductance regulator (CFTR) protein. Because CF is an orphan disease, therapeutic strategies aimed at improving mutant CFTR functi...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Norez, C, Vandebrouck, C, Bertrand, J, Noel, S, Durieu, E, Oumata, N, Galons, H, Antigny, F, Chatelier, A, Bois, P, Meijer, L, Becq, F
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2014
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294108/
https://ncbi.nlm.nih.gov/pubmed/25065395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12859
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